Another important factor is the scale of production. Stainless steel is often used in large-scale bioreactors used in traditional devices, but it is better to use disposable ones for small-scale production. Senior expert Klaus "The problem is scale," Hermanson said. The Danish pharmaceutical engineering company NNE (enolase drug program) process told me: "if the size of the bioreactor is about 500 liters, it is best to use disposable plastic. However, for any bioreactor with a size of 1000 or 2000 liters, there is no material that can really replace stainless steel." This is because the disposable hose that may be discarded instead of the pipe needs an external container to collect, and this must be a stainless steel container with a volume of more than 1000 liters.

Vaccines and biotechnology are small but rapidly developing parts of the pharmaceutical industry. In these small batch, special and flexible production departments, disposable devices are obviously more popular than stainless steel. However, traditional large-scale pharmaceutical plants will continue to use stainless steel. In fact, a considerable number of equipment are used together with disposable components and stainless steel components, so there is an increasing demand for equipment with mixed use of two system materials. To this end, colder's products have developed its steam thru ® Technology, which can create a sterile connection between the non sterilized hose system or short tube assembly and the stainless steel treatment equipment. Its three-way design reduces the risk of contamination caused by the removal of blind pipe sections and allows steam to be directly connected to the steam pipe joints of stainless steel equipment.